Film Coated Tablets Disintegration Time

Dispersible tablets 3 min 15 25º c as per bp.

Film coated tablets disintegration time. The time of disintegration is basically based by the pharmaceuticals keeping in mind the timing of the digestive system so that the medicine is administered at the correct location throat. Film coated tablet 30 min as per bp plain coated tablets dt in specific medium for 30 min as per usp enteric coated tablets dt in simulated gastric fluid 0 1 m hcl for 1 hr and then in simulated intestinal fluid phosphate buffer 6 8 ph until disintegrate as per usp. Remove the assembly from the liquid. Disintegration test dispersible tablets disintegrate within 3 minutes when examined by 5 3 disintegration test for tablets and capsules but using water r at 15 25 c.

Time specified in the individual monograph. Method put one tablet into each tube suspend the assembly in the beaker containing 0 1 m hydrochloric acid and operate without the discs for 2 hours unless otherwise stated in the individual monograph. Disintegration time uncoated tablet nmt 15 min in water with disc 37 0 c 2 0 c coated tablet nmt 30 min in water with disc for film coated tab and nmt 60 min other than film coated tablet enteric coated tab intact for 2 hr in 0 1 n hcl disintegrate within 1 hr in mixed 6 8 phosphate buffer. It was observed that there was proportionate increase in the hardness with the increase in percent weight for all the formulations.

The time taken for this is known as disintegration time. Fineness of dispersion place 2 tablets in 100 ml of water r and stir until completely dispersed. Disintegration times for all other coating trials were less than 360 s. For sugar coated tablets 1 hour.

The other holes are cen plain coated tablets apply the test for un tered 6 0 2 mm from the axis on imaginary linescoated tablets operating the apparatus for the perpendicular to the axis and parallel to each other. For film coated tablets 30min. Excluding these two trials the disintegration time of all samples was very consistent giving a mean increase in disintegration time versus the uncoated core of 120 s. The film coating remnants for trials 11 and 29 were observed to dissolve after 570 and 492 s respectively.

For enteric coated tablets 2 hours. The disintegration time for plain tablet was 10 17 min and for coated tablets 11 55 min 10 45 min 11 21 min 10 47 min 11 21 min 10 45 min 11 42 min all nearer to the value of the plain uncoated tablet table 3.